{"id":514,"date":"2019-02-08T09:29:29","date_gmt":"2019-02-08T09:29:29","guid":{"rendered":"http:\/\/iheart.polimi.it\/?p=514"},"modified":"2025-02-21T08:51:39","modified_gmt":"2025-02-21T08:51:39","slug":"a-transmurally-heterogeneous-orthotropic-activation-model-for-ventricular-contraction-and-its-numerical-validation","status":"publish","type":"post","link":"https:\/\/iheart.polimi.it\/en\/a-transmurally-heterogeneous-orthotropic-activation-model-for-ventricular-contraction-and-its-numerical-validation\/","title":{"rendered":"A transmurally heterogeneous orthotropic activation model for ventricular contraction and its numerical validation"},"content":{"rendered":"<p><em>Luca Barbarotta, Simone Rossi, Luca Ded\u00e8, Alfio Quarteroni<\/em><\/p>\n<p><strong>Int J Numer Meth Biomed Engng<\/strong> Volume 34, Issue 12, December 2018<\/p>\n<p>Open Access: <a href=\"https:\/\/www.mate.polimi.it\/biblioteca\/add\/qmox\/62-2017.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/www.mate.polimi.it\/biblioteca\/add\/qmox\/62-2017.pdf<\/a><br \/>\nDOI: <a href=\"https:\/\/doi.org\/10.1002\/cnm.3137\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/doi.org\/10.1002\/cnm.3137<\/a><\/p>\n<p><strong>Abstract<\/strong>:<\/p>\n<div><span class=\"current-selection\">Models for cardiac mechanics require an activation mechanism properly repre<\/span><span class=\"current-selection\">senting the stress-strain relations in the contracting myocardium. In this paper, <\/span><span class=\"current-selection\">we propose a new activation model that accounts for the transmural hetero<\/span><span class=\"current-selection\">geneities observed in myocardial strain measurements. In order to take the <\/span><span class=\"current-selection\">anisotropy of the active mechanics into account, our model is based on an active <\/span><span class=\"current-selection\">strain formulation. Thanks to multiplicative decomposition of the deformation <\/span><span class=\"current-selection\">gradient tensor, in this formulation, the active strains orthogonal to the fibers <\/span><span class=\"current-selection\">can be naturally described. We compare the results of our novel formulation <\/span><span class=\"current-selection\">against different anisotropic models of the active contraction of the cardiac mus<\/span><span class=\"current-selection\">cle, as well as against experimental data available in the literature. We show that <\/span><span class=\"current-selection\">with the currently available models, the strain distributions are not in agree<\/span><span class=\"current-selection\">ment with the reported experimental measurements. Conversely, we show that <\/span><span class=\"current-selection\">our new transmurally heterogeneous orthotropic activation model improves the <\/span><span class=\"current-selection\">accuracy of shear strains related to in-plane rotations and torsion.<\/span><\/div>\n<div><\/div>\n<div><span class=\"current-selection\">KEYWORDS<\/span><\/div>\n<div><span class=\"current-selection\">active strain formulation, cardiac mechanics, finite element method, transmurally heterogeneous <\/span><span class=\"current-selection\">orthotropic activation<\/span><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Luca Barbarotta, Simone Rossi, Luca Ded\u00e8, Alfio Quarteroni Int J Numer Meth Biomed Engng Volume 34, Issue 12, December 2018 Open Access: https:\/\/www.mate.polimi.it\/biblioteca\/add\/qmox\/62-2017.pdf DOI: https:\/\/doi.org\/10.1002\/cnm.3137 Abstract: Models for cardiac mechanics require an activation mechanism properly representing the stress-strain relations in the contracting myocardium. In this paper, we propose a new [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":515,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[61],"tags":[],"class_list":["post-514","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-papers-en-it-en"],"_links":{"self":[{"href":"https:\/\/iheart.polimi.it\/en\/wp-json\/wp\/v2\/posts\/514","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/iheart.polimi.it\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/iheart.polimi.it\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/iheart.polimi.it\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/iheart.polimi.it\/en\/wp-json\/wp\/v2\/comments?post=514"}],"version-history":[{"count":2,"href":"https:\/\/iheart.polimi.it\/en\/wp-json\/wp\/v2\/posts\/514\/revisions"}],"predecessor-version":[{"id":790,"href":"https:\/\/iheart.polimi.it\/en\/wp-json\/wp\/v2\/posts\/514\/revisions\/790"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/iheart.polimi.it\/en\/wp-json\/wp\/v2\/media\/515"}],"wp:attachment":[{"href":"https:\/\/iheart.polimi.it\/en\/wp-json\/wp\/v2\/media?parent=514"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/iheart.polimi.it\/en\/wp-json\/wp\/v2\/categories?post=514"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/iheart.polimi.it\/en\/wp-json\/wp\/v2\/tags?post=514"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}